Melissa E Elder, M.D., Ph.D.
Professor & Chief
Board Certifications
-
Pediatric RheumatologyAmerican Board of Pediatrics
-
PediatricsAmerican Board of Pediatrics
Clinical Profile
Specialties
- Pediatrics
Subspecialties
- Pediatric Rheumatology
Areas of Interest
- Dermatomyositis
- Granulomatosis with polyangiitis
- Rheumatoid arthritis
- Scleroderma
- Systemic lupus erythematosus
Publications
2020
Rituximab as Adjunct Maintenance Therapy for Refractory Juvenile Myasthenia Gravis.
Pediatric neurology.
111:40-43
[DOI] 10.1016/j.pediatrneurol.2020.07.002.
[PMID] 32951658.
2020
The first case of monozygotic twin boys with nearly identical features of Sjögren’s syndrome.
Rheumatology (Oxford, England).
59(3):687-688
[DOI] 10.1093/rheumatology/kez428.
[PMID] 31566227.
2019
Anakinra as an agent to control hemophagocytic lymphohistiocytosis in Griscelli type 2.
Pediatric blood & cancer.
66(12)
[DOI] 10.1002/pbc.27997.
[PMID] 31535456.
2019
End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.
Clinical nephrology. Case studies.
7:1-6
[DOI] 10.5414/CNCS109510.
[PMID] 30838168.
2019
Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis.
American journal of human genetics.
105(3):549-561
[DOI] 10.1016/j.ajhg.2019.07.014.
[PMID] 31447097.
2019
Overlapping dermatologic diagnoses in severe Crohn’s disease with duel genetic mutations.
International journal of dermatology.
58(11):e214-e216
[DOI] 10.1111/ijd.14520.
[PMID] 31209857.
2019
A Novel Manifestation of Prolidase Deficiency in a Toddler Diagnosed With Very-early-onset Crohn Disease
Journal of Pediatric Gastroenterology and Nutrition.
E89-E90
[DOI] 10.1097/MPG.0000000000002402.
View on:
Publisher’s Site
2017
BK viruria and viremia in children with systemic lupus erythematosus.
Pediatric rheumatology online journal.
15(1)
[DOI] 10.1186/s12969-017-0156-2.
[PMID] 28399927.
2017
Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.).
69(7):1470-1479
[DOI] 10.1002/art.40112.
[PMID] 28371513.
2016
The family journey-to-diagnosis with systemic juvenile idiopathic arthritis: a cross-sectional study of the changing social media presence.
Open access rheumatology : research and reviews.
8:61-71
[PMID] 27843371.
View on:
PubMed
2016
Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener’s): An ARChiVe Cohort Study.
Arthritis & rheumatology (Hoboken, N.J.).
68(10):2514-26
[DOI] 10.1002/art.39729.
[PMID] 27111558.
2014
B-Cell Depletion is Protective Against Anti-AAV Capsid Immune Response: A Human Subject Case Study.
Molecular therapy. Methods & clinical development.
1
[PMID] 25541616.
View on:
PubMed
2014
Tocilizumab in the Treatment of Refractory Uveitis in Children
Annals of the Rheumatic Diseases.
73(2):588-589
[DOI] 10.1136/annrheumdis-2014-eular.3773.
View on:
Publisher’s Site
2013
B-Cell depletion and immunomodulation before initiation of enzyme replacement therapy blocks the immune response to acid alpha-glucosidase in infantile-onset Pompe disease.
The Journal of pediatrics.
163(3):847-54.e1
[DOI] 10.1016/j.jpeds.2013.03.002.
[PMID] 23601496.
2013
The Randomized Placebo Phase Study of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis
Arthritis and Rheumatism.
65:S757-S758
2012
Takayasu’s arteritis: Is it a reversible disease? Case Report and Literature Review.
Surgical neurology international.
3
[DOI] 10.4103/2152-7806.102947.
[PMID] 23227437.
2012
Acute-onset opioid-induced hyperalgesia in a child with juvenile idiopathic arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
18(7):349-51
[DOI] 10.1097/RHU.0b013e31826d2663.
[PMID] 23047535.
2012
Macrophage activation syndrome, an important differential diagnosis for septic shock.
Journal of pediatric intensive care.
1(4):211-216
[DOI] 10.3233/PIC-12035.
[PMID] 31214411.
2011
Immune Modulation in Early Onset Pompe Disease
Molecular Genetics and Metabolism.
102(2):S31-S32
[DOI] 10.1016/j.ymgme.2010.11.107.
View on:
Publisher’s Site
2011
Recombinant adeno-associated virus-mediated gene transfer for the potential therapy of adenosine deaminase-deficient severe combined immune deficiency.
Human gene therapy.
22(8):935-49
[DOI] 10.1089/hum.2010.121.
[PMID] 21142972.
2011
Pompe disease gene therapy.
Human molecular genetics.
20(R1):R61-8
[DOI] 10.1093/hmg/ddr174.
[PMID] 21518733.
2007
Detection of single clone deletions using array CGH: identification of submicroscopic deletions in the 22q11.2 deletion syndrome as a model system.
American journal of medical genetics. Part A.
143A(9):925-32
[PMID] 17394204.
View on:
PubMed
2005
Association between beta2-glycoprotein I gene polymorphisms and pediatric SLE and antiphospholipid antibodies.
Lupus.
14(6):440-4
[PMID] 16038107.
View on:
PubMed
2003
Persistence of vaccine-derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis.
The Journal of infectious diseases.
188(12):1845-52
[PMID] 14673763.
View on:
PubMed
2003
Thrombosis and pediatric Wegener’s granulomatosis: acquired and genetic risk factors for hypercoagulability.
Arthritis and rheumatism.
49(6):862-5
[PMID] 14673976.
View on:
PubMed
2002
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome.
Arthritis and rheumatism.
47(4):414-20
[PMID] 12209489.
View on:
PubMed
2001
Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
Journal of immunology (Baltimore, Md. : 1950).
166(1):656-61
[PMID] 11123350.
View on:
PubMed
2000
T-cell immunodeficiencies.
Pediatric clinics of North America.
47(6):1253-74
[PMID] 11130995.
View on:
PubMed
2000
A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO).
American journal of human genetics.
67(6):1555-62
[PMID] 11047757.
View on:
PubMed
1999
Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count.
The Journal of allergy and clinical immunology.
104(5):1045-51
[PMID] 10550751.
View on:
PubMed
1998
ZAP-70 and defects of T-cell receptor signaling.
Seminars in hematology.
35(4):310-20
[PMID] 9801260.
View on:
PubMed
1996
Severe combined immunodeficiency due to a defect in the tyrosine kinase ZAP-70.
Pediatric research.
39(5):743-8
[PMID] 8726223.
View on:
PubMed
1995
Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency.
Cellular immunology.
165(1):110-7
[PMID] 7671314.
View on:
PubMed
1994
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
Science (New York, N.Y.).
264(5165):1599-601
[PMID] 8202713.
View on:
PubMed
1988
Thymosin and the spontaneously diabetic BB rat.
Autoimmunity.
1(2):115-23
[PMID] 2979610.
View on:
PubMed
1983
Autoimmune diatheses and T lymphocyte immunoincompetences in BB rats.
Metabolism: clinical and experimental.
32(7 Suppl 1):92-6
[PMID] 6345999.
View on:
PubMed
1983
Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.
Journal of immunology (Baltimore, Md. : 1950).
130(4):1723-31
[PMID] 6220066.
View on:
PubMed
Grants
Jul 2020
ACTIVE
University of Florida Pediatric Rheumatology Fellowship Program
Role: Principal Investigator
Funding: ARTHRITIS FOU
Mar 2019
– Mar 2020
A Registry of Patients with Primary Immunodeficiency Disorders
Role: Principal Investigator
Funding: US IMMUNODEFICIENCY NETWORK (USIDNET)
via NATL INST OF HLTH NIAID
Jul 2016
ACTIVE
CMS Newborn Screening – COQWX
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
Jan 2013
ACTIVE
Chronic childhood vasculitis: Characterizing the individual rare diseases to improve patient outcomes
Role: Principal Investigator
Funding: UNIV OF BRITISH COLUMBIA
via CANADIAN INST OF HLTH RES
Jan 2011
– Jun 2016
Genetics/Newborn/Cystic Fibrosis Screening
Role: Project Manager
Funding: FL DEPT OF HLTH
Education
Fellowship – Pediatric Rheumatology
1992
·
University of California – San Francisco
Residency – Pediatrics
1989
·
Johns Hopkins Hospital
Medical School
1986
·
University of Florida
Ph.D – Microbiology & Immunology
1982
·
University of Florida
Teaching Profile
Courses Taught
2013
MDT7400 Elect Top/Pediatrics
2010-2013
MEL7937 Elect Top/Pediatrics
Contact Details
Phones:
- Business:
- (352) 294-5252
Emails:
- Business:
- elderme@peds.ufl.edu