Melissa E Elder

Melissa E Elder, M.D., Ph.D.

Professor & Chief

Department: MD-PATHOLOGY
Business Phone: (352) 294-5252
Business Email: elderme@peds.ufl.edu

Board Certifications

  • Pediatric Rheumatology
    American Board of Pediatrics
  • Pediatrics
    American Board of Pediatrics

Clinical Profile

Specialties
  • Pediatrics
Subspecialties
  • Pediatric Rheumatology
Areas of Interest
  • Dermatomyositis
  • Granulomatosis with polyangiitis
  • Rheumatoid arthritis
  • Scleroderma
  • Systemic lupus erythematosus

Publications

2020
Rituximab as Adjunct Maintenance Therapy for Refractory Juvenile Myasthenia Gravis.
Pediatric neurology. 111:40-43 [DOI] 10.1016/j.pediatrneurol.2020.07.002. [PMID] 32951658.
2020
The first case of monozygotic twin boys with nearly identical features of Sj√∂gren’s syndrome.
Rheumatology (Oxford, England). 59(3):687-688 [DOI] 10.1093/rheumatology/kez428. [PMID] 31566227.
2019
Anakinra as an agent to control hemophagocytic lymphohistiocytosis in Griscelli type 2.
Pediatric blood & cancer. 66(12) [DOI] 10.1002/pbc.27997. [PMID] 31535456.
2019
End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.
Clinical nephrology. Case studies. 7:1-6 [DOI] 10.5414/CNCS109510. [PMID] 30838168.
2019
Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis.
American journal of human genetics. 105(3):549-561 [DOI] 10.1016/j.ajhg.2019.07.014. [PMID] 31447097.
2019
Overlapping dermatologic diagnoses in severe Crohn’s disease with duel genetic mutations.
International journal of dermatology. 58(11):e214-e216 [DOI] 10.1111/ijd.14520. [PMID] 31209857.
2019
A Novel Manifestation of Prolidase Deficiency in a Toddler Diagnosed With Very-early-onset Crohn Disease
Journal of Pediatric Gastroenterology and Nutrition. E89-E90 [DOI] 10.1097/MPG.0000000000002402.
2017
BK viruria and viremia in children with systemic lupus erythematosus.
Pediatric rheumatology online journal. 15(1) [DOI] 10.1186/s12969-017-0156-2. [PMID] 28399927.
2017
Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.). 69(7):1470-1479 [DOI] 10.1002/art.40112. [PMID] 28371513.
2016
The family journey-to-diagnosis with systemic juvenile idiopathic arthritis: a cross-sectional study of the changing social media presence.
Open access rheumatology : research and reviews. 8:61-71 [PMID] 27843371.
View on: PubMed
2016
Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener’s): An ARChiVe Cohort Study.
Arthritis & rheumatology (Hoboken, N.J.). 68(10):2514-26 [DOI] 10.1002/art.39729. [PMID] 27111558.
2014
B-Cell Depletion is Protective Against Anti-AAV Capsid Immune Response: A Human Subject Case Study.
Molecular therapy. Methods & clinical development. 1 [PMID] 25541616.
View on: PubMed
2014
Tocilizumab in the Treatment of Refractory Uveitis in Children
Annals of the Rheumatic Diseases. 73(2):588-589 [DOI] 10.1136/annrheumdis-2014-eular.3773.
2013
B-Cell depletion and immunomodulation before initiation of enzyme replacement therapy blocks the immune response to acid alpha-glucosidase in infantile-onset Pompe disease.
The Journal of pediatrics. 163(3):847-54.e1 [DOI] 10.1016/j.jpeds.2013.03.002. [PMID] 23601496.
2013
The Randomized Placebo Phase Study of Rilonacept in the Treatment of Systemic Juvenile Idiopathic Arthritis
Arthritis and Rheumatism. 65:S757-S758
2012
Takayasu’s arteritis: Is it a reversible disease? Case Report and Literature Review.
Surgical neurology international. 3 [DOI] 10.4103/2152-7806.102947. [PMID] 23227437.
2012
Acute-onset opioid-induced hyperalgesia in a child with juvenile idiopathic arthritis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 18(7):349-51 [DOI] 10.1097/RHU.0b013e31826d2663. [PMID] 23047535.
2012
Macrophage activation syndrome, an important differential diagnosis for septic shock.
Journal of pediatric intensive care. 1(4):211-216 [DOI] 10.3233/PIC-12035. [PMID] 31214411.
2011
Immune Modulation in Early Onset Pompe Disease
Molecular Genetics and Metabolism. 102(2):S31-S32 [DOI] 10.1016/j.ymgme.2010.11.107.
2011
Recombinant adeno-associated virus-mediated gene transfer for the potential therapy of adenosine deaminase-deficient severe combined immune deficiency.
Human gene therapy. 22(8):935-49 [DOI] 10.1089/hum.2010.121. [PMID] 21142972.
2011
Pompe disease gene therapy.
Human molecular genetics. 20(R1):R61-8 [DOI] 10.1093/hmg/ddr174. [PMID] 21518733.
2007
Detection of single clone deletions using array CGH: identification of submicroscopic deletions in the 22q11.2 deletion syndrome as a model system.
American journal of medical genetics. Part A. 143A(9):925-32 [PMID] 17394204.
View on: PubMed
2005
Association between beta2-glycoprotein I gene polymorphisms and pediatric SLE and antiphospholipid antibodies.
Lupus. 14(6):440-4 [PMID] 16038107.
View on: PubMed
2003
Persistence of vaccine-derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis.
The Journal of infectious diseases. 188(12):1845-52 [PMID] 14673763.
View on: PubMed
2003
Thrombosis and pediatric Wegener’s granulomatosis: acquired and genetic risk factors for hypercoagulability.
Arthritis and rheumatism. 49(6):862-5 [PMID] 14673976.
View on: PubMed
2002
Anti-beta2-glycoprotein I antibodies in pediatric systemic lupus erythematosus and antiphospholipid syndrome.
Arthritis and rheumatism. 47(4):414-20 [PMID] 12209489.
View on: PubMed
2001
Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
Journal of immunology (Baltimore, Md. : 1950). 166(1):656-61 [PMID] 11123350.
View on: PubMed
2000
T-cell immunodeficiencies.
Pediatric clinics of North America. 47(6):1253-74 [PMID] 11130995.
View on: PubMed
2000
A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO).
American journal of human genetics. 67(6):1555-62 [PMID] 11047757.
View on: PubMed
1999
Cytokine profile of a long-term pediatric HIV survivor with hyper-IgE syndrome and a normal CD4 T-cell count.
The Journal of allergy and clinical immunology. 104(5):1045-51 [PMID] 10550751.
View on: PubMed
1998
ZAP-70 and defects of T-cell receptor signaling.
Seminars in hematology. 35(4):310-20 [PMID] 9801260.
View on: PubMed
1996
Severe combined immunodeficiency due to a defect in the tyrosine kinase ZAP-70.
Pediatric research. 39(5):743-8 [PMID] 8726223.
View on: PubMed
1995
Severe combined immunodeficiency with absence of peripheral blood CD8+ T cells due to ZAP-70 deficiency.
Cellular immunology. 165(1):110-7 [PMID] 7671314.
View on: PubMed
1994
ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
Science (New York, N.Y.). 264(5165):1599-601 [PMID] 8202713.
View on: PubMed
1988
Thymosin and the spontaneously diabetic BB rat.
Autoimmunity. 1(2):115-23 [PMID] 2979610.
View on: PubMed
1983
Autoimmune diatheses and T lymphocyte immunoincompetences in BB rats.
Metabolism: clinical and experimental. 32(7 Suppl 1):92-6 [PMID] 6345999.
View on: PubMed
1983
Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.
Journal of immunology (Baltimore, Md. : 1950). 130(4):1723-31 [PMID] 6220066.
View on: PubMed

Grants

Jul 2020 ACTIVE
University of Florida Pediatric Rheumatology Fellowship Program
Role: Principal Investigator
Funding: ARTHRITIS FOU
Mar 2019 – Mar 2020
A Registry of Patients with Primary Immunodeficiency Disorders
Role: Principal Investigator
Funding: US IMMUNODEFICIENCY NETWORK (USIDNET) via NATL INST OF HLTH NIAID
Jul 2016 ACTIVE
CMS Newborn Screening – COQWX
Role: Principal Investigator
Funding: FL DEPT OF HLTH CHILDRENS MED SERVS
Jan 2013 ACTIVE
Chronic childhood vasculitis: Characterizing the individual rare diseases to improve patient outcomes
Role: Principal Investigator
Funding: UNIV OF BRITISH COLUMBIA via CANADIAN INST OF HLTH RES
Jan 2011 – Jun 2016
Genetics/Newborn/Cystic Fibrosis Screening
Role: Project Manager
Funding: FL DEPT OF HLTH

Education

Fellowship – Pediatric Rheumatology
1992 · University of California – San Francisco
Residency – Pediatrics
1989 · Johns Hopkins Hospital
Medical School
1986 · University of Florida
Ph.D – Microbiology & Immunology
1982 · University of Florida

Teaching Profile

Courses Taught
2013
MDT7400 Elect Top/Pediatrics
2010-2013
MEL7937 Elect Top/Pediatrics

Contact Details

Phones:
Business:
(352) 294-5252
Emails: