Amyotrophic Lateral Sclerosis

Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease (AIH in ALS)

About: Most ALS patients survive less than 5 years after diagnosis, and the main cause of death is respiratory failure. The investigators are interested in the therapeutic potential of acute intermittent hypoxia (AIH) for individuals with neuromuscular diseases, such as ALS. More than two decades of research indicates AIH elicits meaningful respiratory and non-respiratory motor recovery. Acute intermittent hypoxia (AIH) consists of alternating periods of breathing mildly hypoxic (lowered oxygen concentration) and normoxic (normal oxygen concentration) air.

The investigators propose to study mechanisms of respiratory plasticity associated with a single presentation of mild AIH. The fundamental hypothesis guiding this proposal is that even a single AIH trial improves respiratory (and non-respiratory) motor function in ALS patients procedure. Participants will then be asked to breathe air with reduced oxygen for short periods of time, for a duration of 45 minutes. The activity of your muscles and your heart function will be monitored throughout the procedure.

Ages Eligible for Study: 30 Years to 75 Years (Adult, Older Adult)

Sexes Eligible for Study:  Male and Female

Status:  Actively recruiting participants.

Join the Study

For more information about this study, including eligibility criteria, please go to the study’s page. If you are interested in participating in this study or have questions about research, please contact Jessica Ehrbar, Clinical Research Coordinator.